Rectopanbiline gel was a rectal laxative drug used for the treatment of constipation in the early 1970s. The product – a gel microenema – contained a bovine bile fluid extract (titrated to 12 % cholic acid), gelatin, and glycerin. The drug helped the bowel to open, possibly producing faster results than suppositories. The product served as a fast and effective relief of intestinal symptoms. It was also used occasionally to prepare to and to facilitate endoscopic examination of the rectum. Bile acids (such as chenodeoxycholic acid) remain well used today to treat constipation. They can efficiently modify colonic motility through direct effects on colonic neuromuscular activity independently of secretory effects. The drug product can still be found today to relieve constipation (Rectopanbiline rectal gel beef bile extract monodoses) but suppositories are usually preferred (at least in France).
