Read a new publication from Oncowitan: Withanolides represent an important class of bioactive natural products with a steroidal lactone core. The covalent binding of the major withanolides to cysteine residues in proteins is detailed. About 20 proteins targets have been defined and the conjugation of their α,β-unsaturated carbonyl system has been well characterized. A unique overview of the binding mechanism.
Covalent binding of withanolides to cysteines of protein targets,
Biochemical Pharmacology (2024)
