The drug “Liotripsil oral balsamique” was used to treat bronchitis and sinusitis, alone or in combination with antibiotics to help their penetration of the into respiratory secretions. This complex product was a fluidifying agent containing the proteolytic enzymes trypsin and α-chymotrypsin useful to disrupt mucopolysaccharides of bronchial secretions. The product was recommended to treat both acute and chronic bronchopneumopathies. This enzymatic therapy combining two proteolytic enzymes contained also (i) terpine which is a small molecule with an expectorant action to facilitate mucus elimination during bronchitis, (ii) glyceryl guaiacolate (also known as guaifenesin) which has also mucolytic and expectorant properties and (iii) calcium camphorsulfonate (probably as a solubilizing agent). The drug is no longer used today but many other drugs containing a combination of trypsin and α-chymotrypsin proteolytic enzymes can be found on the market, notably to treat swelling and edema.
